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The gut makes dozens of hormones, and many of them travel to the brain receptors that either curb appetite or stimulate it, Drucker explains
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Back Weir, GC, Mojsov, S, Hendrick, GK, Habener, JE (March 1989) 'Glucagonlike peptide I (7-37) actions on endocrine pancreas', Diabetes , 38, 338-42